ЛЕКЦИИ
32
РЕФЛЕКСОТЕРАПИЯ И КОМПЛЕМЕНТАРНАЯ МЕДИЦИНА
№ 1 (23) 2018
din D derived from roots of Platycodon grandi-
florum in human endothelial cells. Biol Pharm
Bull. 2012;35 (8):1216-21. PMID: 22863916.
12. Ryu CS, Kim CH, Lee SY, Lee KS, Choung
KJ, Song GY, Kim BH, Ryu SY, Lee HS, Kim
SK. Evaluation of the total oxidant scavenging
capacity of saponins isolated from
Platycodon
grandiflorum
. Food Chem. 2012;132:333-337.
PMID: 26434298.
13. Choi JH, Jin SW, Choi CY, Kim HG, Kim SJ,
Lee HS, Chung YC, Kim EJ, Lee YC, Jeong
HG. Saponins from the roots of Platycodon
grandiflorum ameliorate high fat diet-induced
non-alcoholic steatohepatitis. Biomed Phar-
macother. 2017 Feb;86:205-212. doi: 10.1016/j.
biopha.2016.11.107. PMID: 27984800.
14. Chung JW, Noh EJ, Zhao HL, Sim JS, Ha YW,
Shin EM, Lee EB, Cheong CS, Kim YS. Anti-
inflammatory activity of prosapogenin methyl
ester of platycodin D via nuclear factor-kap-
paB pathway inhibition. Biol Pharm Bull. 2008
Nov;31 (11):2114-20. PMID: 18981583.
15. Kim JY, Hwang YP, Kim DH, Han EH, Chung
YC, Roh SH, Jeong HG. Inhibitory effect of the
saponins derived from roots of Platycodon gran-
diflorum on carrageenan-induced inflamma-
tion. Biosci Biotechnol Biochem. 2006 Apr;70
(4):858-64. PMID: 16636452.
16. Wu JT, Yang GW, Qi CH, Zhou L, Hu JG,
Wang MS. Anti-inflammatory activity of plat-
ycodin D on alcohol-induced fatty liver rats
via TLR4-MYD88-NF-κB signal path. Afr J
Tradit Complement Altern Med. 2016 Jul 3;13
(4):176-183. doi: 10.21010/ajtcam.v13i4.23.
PMID: 28852734.
17. Choi JH, Jin SW, Kim HG, Choi CY, Lee HS,
Ryu SY, Chung YC, Hwang YJ, Um YJ, Jeong
TC, Jeong HG. Saponins, especially platyconic
acid A, from Platycodon grandiflorum reduce
airway inflammation in ovalbumin-induced
mice and PMA-exposed A549 cells. J Agric
Food Chem. 2015 Feb 11;63 (5):1468-76. doi:
10.1021/jf5043954. PMID: 25590691.
18. Tao W, Su Q, Wang H, Guo S, Chen Y, Duan
J, Wang S. Platycodin D attenuates acute lung
injury by suppressing apoptosis and inflamma-
tion in vivo and in vitro. Int Immunopharma-
col. 2015 Jul;27 (1):138-47. doi: 10.1016/j.in-
timp.2015.05.005. PMID: 25981110.
19. Lee SJ, Bang WS, Hong JS, Kwon OJ, Shin SR,
Yoon KY. Antioxidant and antimicrobial activi-
ties of black Doraji (Platycodon grandiflorum)
Korean J Food Preserv. 2013;20:510-517.
20. Shin CY, Lee WJ, Lee EB, Choi EY, Ko KH.
Platycodin D and D3 increase airway mucin re-
lease in vivo and in vitro in rats and hamsters.
Planta Med. 2002 Mar;68 (3):221-5. PMID:
11914958.
21. Ryu J, Lee HJ, Park SH, Kim J, Lee D, Lee SK,
Kim YS, Hong JH, Seok JH, Lee CJ. Effects of
the root of Platycodon grandiflorum on airway
mucin hypersecretion in vivo and platycodin
D (3) and deapi-platycodin on production and
secretion of airway mucin in vitro. Phytomedi-
cine. 2014 Mar 15;21 (4):529-33. doi: 10.1016/j.
phymed.2013.10.004. PMID: 24290472.
22. Han SB, Park SH, Lee KH, Lee CW, Lee SH,
Kim HC, Kim YS, Lee HS, Kim HM. Polysac-
charide isolated from the radix of Platycodon
grandiflorumselectively activates Bcells andmac-
rophages but not T cells. Int Immunopharmacol.
2001 Oct;1 (11):1969-78. PMID: 11606028.
23. Lee KJ, Kim JY, Choi JH, KimHG, Chung YC,
Roh SH, Jeong HG. Inhibition of tumor inva-
sion and metastasis by aqueous extract of the
radix of Platycodon grandiflorum. Food Chem
Toxicol. 2006 Nov;44 (11):1890-6. PMID:
16890340.
24. Wu J, Yang G, Wen W, Zhang F, Yuan J,
An L. Cholesterol metabolism regulation and
antioxidant effect of platycodin D on hyper-
lipidemic emulsion-reduced rats. Afr J Pharm
Pharmacol. 2011;5:2444-2453.
25. Lee CE, Hur HJ, Hwang JT, Sung MJ, Yang
HJ, Kim HJ, Park JH, Kwon DY, Kim MS.
Long-Term Consumption of Platycodi Radix
Ameliorates Obesity and Insulin Resistance via
the Activation of AMPK Pathways. Evid Based
Complement Alternat Med. 2012;2012:759143.
doi: 10.1155/2012/759143. PMID: 22829857.
26. Lee EJ, Kang M, Kim YS. Platycodin D in-
hibits lipogenesis through AMPKα-PPARγ
2
in 3T3-L1 cells and modulates fat accumula-
tion in obese mice. Planta Med. 2012 Sep;78
(14):1536-42. PMID: 22872592.
27. Kim JY, Kim DH, Kim HG, Song GY, Chung
YC, Roh SH, Jeong HG. Inhibition of tumor
necrosis factor-alpha-induced expression of ad-
hesion molecules in human endothelial cells by
the saponins derived from roots of Platycodon
grandiflorum. Toxicol Appl Pharmacol. 2006
Jan 1;210 (1-2):150-6. PMID: 16271738.
28. Kim YJ, Choi JY, Ryu R, Lee J, Cho SJ, Kwon
EY, Lee MK, Liu KH, Rina Y, Sung MK,
Choi MS. Platycodon grandiflorus Root Ex-
tract Attenuates Body Fat Mass, Hepatic Stea-
tosis and Insulin Resistance through the In-
terplay between the Liver and Adipose Tissue.
Nutrients. 2016 Aug 30;8 (9). pii: E532. doi:
10.3390/nu8090532. PMID: 27589792.
29. Zheng J, He J, Ji B, Li Y, Zhang X. Antihyper-
glycemic effects of Platycodon grandiflorum