ЛЕКЦИИ
12
РЕФЛЕКСОТЕРАПИЯ И КОМПЛЕМЕНТАРНАЯ МЕДИЦИНА
№ 2 (24) 2018
29. He K, Li X, Chen X, Ye X, Huang J, Jin Y, Li P,
Deng Y, Jin Q, Shi Q, Shu H. Evaluation of anti-
diabetic potential of selected traditional Chinese
medicines in STZ-induced diabetic mice. J Eth-
nopharmacol. 2011 Oct 11;137 (3):1135-42. doi:
10.1016/j.jep.2011.07.033. PMID: 21798327.
30. Hoa NK, Phan DV, Thuan ND, Ostenson CG.
Insulin secretion is stimulated by ethanol extract
of Anemarrhena asphodeloides in isolated islet
of healthy Wistar and diabetic Goto-Kakiza-
ki Rats. Exp Clin Endocrinol Diabetes. 2004
Oct;112 (9):520-5. PMID: 15505760.
31. Nakashima N, Kimura I, Kimura M, Matsuu-
ra H. Isolation of pseudoprototimosaponin AIII
from rhizomes of Anemarrhena asphodeloides
and its hypoglycemic activity in streptozotocin-
induced diabetic mice. J Nat Prod. 1993 Mar;56
(3):345-50. PMID: 8482946.
32. Li X, Cui X, Sun X, Li X, Zhu Q, Li W. Man-
giferin prevents diabetic nephropathy progres-
sion in streptozotocin-induced diabetic rats.
Phytother Res. 2010 Jun;24 (6):893-9. doi:
10.1002/ptr.3045. PMID: 19960420.
33. Guo C, Li L, Yang X, Meng Z, Li F, Zhang
C, Yang Z. Protective effects of timosaponin
B-II on high glucose-induced apoptosis in hu-
man umbilical vein endothelial cells. Environ
Toxicol Pharmacol. 2014 Jan;37 (1):37-44. doi:
10.1016/j.etap.2013.11.009. PMID: 24295731.
34. Cong Y, Wang L, Peng R, Zhao Y, Bai F, Yang
C, Liu X, Wang D, Ma B, Cong Y. Timosapo-
nin AIII induces antiplatelet and antithrombotic
activity via Gq-mediated signaling by the throm-
boxane A2 receptor. Sci Rep. 2016 Dec 9;6:38757.
doi: 10.1038/srep38757. PMID: 27934923.
35. Oh JK, Hyun SY, Oh HR, Jung JW, Park C, Lee
SY, Park JH, Kim SY, Kim KH, Kim YK, Ryu
JH.Effects of Anemarrhena asphodeloides on
focal ischemic brain injury induced by middle
cerebral artery occlusion in rats. Biol Pharm
Bull. 2007 Jan;30 (1):38-43. PMID: 17202656.
36. Sun Y, Peng Y, Li LG, Zheng LW, Lin DJ, Li
LZ, Song SJ. A Platform for Screening Potential
Anticholinesterase Fractions and Components
Obtained from Anemarrhena asphodeloides Bge
for Treating Alzheimer»s Disease. Evid Based
Complement Alternat Med. 2014;2014:524650.
doi: 10.1155/2014/524650. PMID: 24864153.
37. Huang JF, Shang L, Liu P, Zhang MQ, Chen S,
Chen D, Fan CL, Wang H, Xiong K. Timosapo-
nin-BII inhibits the up-regulation of BACE1 in-
duced by ferric chloride in rat retina. BMC Com-
plement Altern Med. 2012 Oct 22;12:189. doi:
10.1186/1472-6882-12-189. PMID: 23082924.
38. Wang ZD, Yao GD, Wang W, Wang WB,
Wang SJ, Song SJ. Synthesis and evalua-
tion of 26-amino acid methyl ester substituted
sarsasapogenin derivatives as neuroprotec-
tive agents for Alzheimer»s disease. Steroids.
2017 Sep;125:93-106. doi: 10.1016/j.ste-
roids.2017.06.013. PMID: 28687235.
39. Lee B, Jung K, Kim DH. Timosaponin AIII, a
saponin isolated fromAnemarrhena asphodeloi-
des, ameliorates learning and memory deficits in
mice. Pharmacol Biochem Behav. 2009 Aug;93
(2):121-7.
doi:
10.1016/j.pbb.2009.04.021.
PMID:19426756.
40. Jung K, Lee B, Han SJ, Ryu JH, Kim DH.
Mangiferin ameliorates scopolamine-induced
learning deficits in mice. Biol Pharm Bull. 2009
Feb;32 (2):242-6. PMID: 19182383.
41. Lu L, Ding Y, Zhang Y, Ho RJ, Zhao Y, Zhang
T, Guo C. Antibody-modified liposomes for tu-
mor-targeting delivery of timosaponin AIII. Int
J Nanomedicine. 2018 Mar 29;13:1927-1944.
doi: 10.2147/ljN.S153107. eCollection 2018.
PMID: 29636610.
42. King FW, Fong S, Griffin C, Shoemaker M,
Staub R, Zhang YL, Cohen I, Shtivelman E. Ti-
mosaponin AIII is preferentially cytotoxic to
tumor cells through inhibition of mTOR and in-
duction of ER stress. PLoS One. 2009 Sep 30;4
(9):e7283. doi: 10.1371/journal.pone.0007283.
PMID: 19789631.
43. Kim KM, Im AR, Kim SH, Hyun JW,
Chae S. Timosaponin AIII inhibits melanoma
cell migration by suppressing COX-2 and in
vivo tumor metastasis. Cancer Sci. 2016 Feb;107
(2):181-8. doi: 10.1111/cas.12852. PMID:
26595378.
44. Gergely JE, Dorsey AE, Dimri GP, Dim-
ri M. Timosaponin A-III inhibits oncogenic
phenotype via regulation of PcG protein BMI1
in breast cancer cells. Mol Carcinog. 2018 Mar
12. doi: 10.1002/mc.22804. PMID: 29528145.
45. Shen S, Zhang Y, Zhang R, Gong X. Sarsasapo-
genin induces apoptosis via the reactive oxygen
species-mediated mitochondrial pathway and
ER stress pathway in HeLa cells. Biochem Bio-
phys Res Commun. 2013 Nov 15;441 (2):519-24.
PMID: 24383086.
46. Wang W, Zhang Y, Yao G, Wang W, Shang X,
Zhang Y, Wang X, Wang S, Song S. Synthesis
of new sarsasapogenin derivatives with antipro-
liferative and apoptotic effects in MCF-7 cells.
Steroids. 2018 Mar;131:23-31. doi: 10.1016/j.ste-
roids.2018.01.001. PMID: 29337037.